The CD30 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to TNFRSF8. This antibody recognizes Human antigen. The CD30 Antibody has been validated for the following applications: ELISA, Flow Cytometry, and Western Blot.
Description
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Function: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Subunit Structure: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
Post-translational Modifications: Phosphorylated on serine and tyrosine residues